I grew up on a desktop. There was often more than 2 or 3 in my home since we had so many kids. Desktops are great due to the fact they provide more disk space for the most part.
I have been using a laptop for the last 5 years or so now and have gotten used to the ease of the built in keyboard. My fingers are so used to flying across the keys, where as with my husband's desktop, I feel like I am back in my first typing class.
I also enjoy the freedom of being able to take my laptop outside in the backyard while my children play.